The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race (Hardcover)

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Description


The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.

Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.

The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.

Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?

After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.

About the Author


Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da VinciThe Innovators; Steve JobsEinstein: His Life and UniverseBenjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.

Praise For…


“This year’s prize is about rewriting the code of life. These genetic scissors have taken the life sciences into a new epoch.” – Announcement of the 2020 Nobel Prize in Chemistry

"Walter Isaacson is our Renaissance biographer, a writer of unusual range and depth who has plumbed lives of genius to illuminate fundamental truths about human nature. From Leonardo to Steve Jobs, from Benjamin Franklin to Albert Einstein, Isaacson has given us an unparalleled canon of work that chronicles how we have come to live the way we do. Now, in a magnificent, compelling, and wholly original book, he turns his attention to the next frontier: that of gene editing and the role science may play in reshaping the nature of life itself. This is an urgent, sober, accessible, and altogether brilliant achievement." —Jon Meacham

"When a great biographer combines his own fascination with science and a superb narrative style, the result is magic. This important and powerful work, written in the tradition of The Double Helix, allows us not only to follow the story of a brilliant and inspired scientist as she engages in a fierce competitive race, but to experience for ourselves the wonders of nature and the joys of discovery." —Doris Kearns Goodwin

“He’s done it again. The Code Breaker is another Walter Isaacson must-read. This time he has a heroine who will be for the ages; a worldwide cast of remarkable, fiercely competitive scientists; and a string of discoveries that will change our lives far more than the iPhone did. The tale is gripping. The implications mind-blowing.” – Atul Gawande

"An extraordinary book that delves into one of the most path-breaking biological technologies of our times and the creators who helped birth it. This brilliant book is absolutely necessary reading for our era."  — Siddhartha Mukherjee

“Now more than ever we should appreciate the beauty of nature and the importance of scientific research; This book and Jennifer Doudna’s career show how thrilling it can be to understand how life works.” —Sue Desmond-Hellmann

"A vital book about the next big thing in science—and yet another top-notch biography from Isaacson." — Kirkus Reviews (starred review)

"In Isaacson's splendid saga of how big science really operates, curiosity and creativity, discovery and innovation, obsession and strong personalities, competitiveness and collaboration, and the beauty of nature all stand out." — Booklist (starred review)

"Isaacson depicts science at its most exhilarating in this lively biography of Jennifer Doudna, the winner of the 2020 Nobel Prize in medicine for her work on the CRISPR system of gene editing...The result is a gripping account of a great scientific advancement and of the dedicated scientists who realized it." — Publisher's Weekly (starred review)

"Isaacson, the Pulitzer Prize-winning author of best sellers Leonardo da Vinci and Steve Jobs, offers a startling, insightful look at this lifesaving, hugely significant scientific advancement and the brilliant Doudna, who wrestles with the serious moral questions that accompany her creation. Should this technology be offered to parents to tailor-make their babies into athletes or Einsteins? Who gets altered and saved and why?” AARP

"The journalist who told the life stories of Leonardo da Vinci and Steve Jobs is back with a timely biography of Jennifer Doudna, PhD, winner of the 2020 Nobel Prize in chemistry. It’s a fast-paced account of her life as a pathbreaking scientist on CRISPR — and how gene editing could alter all life as we know it." Medium

"This challenging, fascinating story examines Doudna's background and excavates the moral quandaries she grapples with as her creation opens up more and more avenues for scientific advancement." Elle

"It is a gripping tale, showing how our new ability to hack evolution will soon start throwing us curveballs." New Scientist
Product Details
ISBN: 9781982115852
ISBN-10: 1982115858
Publisher: Simon & Schuster
Publication Date: March 9th, 2021
Pages: 560
Language: English